GW610742 hmoov
Khoom npe: GW 0742
Alias: GW 610742, GW-0742
CAS: 317318-84-6
MF: C21H17F4NO3S2
Purity: 99.50%
Noj: 20-30mg ib hnub twg
Qib: Pharmaceutical Qib
Qhov tsos: Dawb hmoov
packing Methods: tsim txoj kev ntim khoom disguised, 100% dhau kev cai lav
Kev Them Nyiaj: T / T, Western Union, Nyiaj Gram, Bitcoin
Kev Siv: GW 0742 tau tshawb xyuas raws li kev kho mob rau kev rog rog, ntshav qab zib, dyslipidemia thiab kab mob plawv.
Nqe lus piav qhia:
GW0742, tseem hu ua GW610742, yog PPAR agonist. GW0742 Induces Early Neuronal Maturation ntawm Cortical Post-Mitotic Neurons. GW0742 tiv thaiv kev kub ntxhov, vascular inflammatory thiab oxidative xwm txheej, thiab endothelial dysfunction nyob rau hauv kev noj haus vim rog. GW0742 muaj kev tiv thaiv ncaj qha rau ntawm txoj cai lub plawv hypertrophy. GW0742 tuaj yeem txhim kho lipid metabolism hauv plawv ob leeg hauv vivo thiab hauv vitro.
Daim ntawv thov
GW 0742 activates AMP-activated protein kinase thiab txhawb nqa cov piam thaj hauv cov leeg nqaij pob txha, thiab GW 501516 tau pom tias rov qab metabolic abnormality nyob rau hauv cov txiv neej rog nrog pre-diabetic metabolic syndrome, feem ntau yuav los ntawm stimulating fatty acid oxidation.
GW0742 tau raug npaj los ua ib qho kev kho mob rau kev rog rog thiab lwm yam mob, tshwj xeeb tshaj yog thaum siv nrog kev sib koom ua ke nrog AICAR, raws li kev sib xyaw ua ke tau pom tias yuav ua rau muaj kev tawm dag zog ntau hauv tib neeg.
Cov teebmeem tseem ceeb
Nce nyob rau hauv endurance
Ua kom muaj zog
Txo cov roj (cholesterol) phem (LDL)
Nce cov roj cholesterol zoo (HDL)
Hlawv rog
Txo qhov mob
Kev siv:
GW0742 yog ib tug me me molecule agonist ntawm tib neeg Peroxisome Proliferator-Activated Recept δ (PPAR δ). Nws qhia tau hais tias EC50 ntawm 1.1 nM tawm tsam PPAR δ nrog 100-fold selectivity dua lwm tus tib neeg subtypes.
GW0742 ua haujlwm li cas?
Qhov kev tiv thaiv siab tshaj plaws rau GW0742 tau pom rau VDR thiab androgen receptor (AR). Kuj ceeb tias, GW0742 coj tus cwj pwm li PPAR agonist / antagonist activating transcription ntawm qis concentration thiab inhibiting cov nyhuv ntawm ntau dua concentration. Ib qho tshwj xeeb spectroscopic khoom ntawm GW0742 tau txheeb xyuas thiab. Nyob rau hauv lub xub ntiag ntawm rhodamine-derived molecules, GW0742+ nce fluorescence siv thiab fluorescence polarization ntawm ib tug excitation wavelength ntawm 595 nm thiab emission wavelength ntawm 615 nm nyob rau hauv ib koob tshuaj raws li.
GW0742-inhibited NR-coactivator binding ua rau txo qis ntawm tsib lub hom phiaj NR hom noob hauv LNCaP hlwb nyob rau hauv lub xub ntiag ntawm agonist. Tshwj xeeb tshaj yog VDR cov hom phiaj CYP24A1, IGFBP-3 thiab TRPV6 tau tswj tsis zoo los ntawm GW0742. GW0742 yog thawj VDR ligand inhibitor tsis muaj cov qauv secosteroid ntawm VDR ligand antagonists. Txawm li cas los xij, VDR-meditated downstream txheej txheem ntawm kev sib txawv ntawm tes tau antagonized los ntawm GW0742 hauv HL-60 hlwb uas tau pretreated nrog endogenous VDR agonist 1,25-dihydroxyvitamin D3.
Cim npe nrov: gw610742, Tuam Tshoj gw610742 lwm tus neeg
