Product details
Khoom npe: Orlistat hmoov
CAS Nr.: 96829-58-2
MF: C29H53NO5
Einecs No: 115074-43-6
Purity: 99. 0%
Qhov tsos: Dawb hmoov
Cia Kub: Khaws rau hauv qhov chaw txias, qhuav, tsaus rau hauv lub thawv kaw nruj nreem lossis lub tog raj kheej.
Kev piav qhia
Orlistat hmoov yog cov tshuaj kho mob rog uas tsis ua rau lub hauv nruab nrab lub paj hlwb. Nws tsuas yog ua rau lub plab zom mov. Orlistat hmoov tiv thaiv cov hydrolysis ntawm triacylglycerols rau hauv cov roj fatty acids dawb thiab monoacylglycerides los ntawm inhibiting lipase ntawm txoj hnyuv, txo qhov nqus ntawm cov rog (triacylglycerol) los ntawm txoj hnyuv mucosa, thiab txhawb kev tshem tawm cov rog ntawm lub cev.
1. Orlistat yog siv nrog cov khoom noj uas muaj calorie tsawg los pab koj poob phaus thiab tswj koj qhov hnyav tom qab poob phaus.
2. Orlistat yog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua lipase inhibitors. Nws ua haujlwm hauv koj cov hnyuv, qhov twg nws thaiv qee cov roj uas koj noj los ntawm kev nqus thiab zom. Cov roj undigested no raug tshem tawm hauv koj lub plab zom mov.
COA
|
Yam khoom |
Cov txiaj ntsig |
Specifications |
|
Kev piav qhia |
Dawb los yog yuav luag dawb crystalline hmoov, tsw-tsawg |
Ua raws |
|
Kev txheeb xyuas |
Qhov tshwm sim ntawm HPLC zoo ib yam rau qhov siv ib qho. |
Ua raws |
|
Qhov tshwm sim ntawm IR yog zoo ib yam rau ib qho kev siv. |
||
|
Melting Point |
42 ~ 46 degree |
43 ~ 44 degree |
|
Kev sib hloov tshwj xeeb |
{{0}} 0 degree ~ -37.0 degree (CHCl3,C=1) |
-34.5 degree |
|
Tag nrho impurity |
Tsis ntau tshaj 2.0% |
0.71% |
|
Ib qho impurity |
Tsis ntau tshaj 0.30% |
0.21% |
|
Chloride |
Tsis ntau tshaj 200ppm |
ua raws |
|
Sulfate |
Tsis ntau tshaj 500ppm |
ua raws |
|
Residual ntawm Ignition |
Tsis ntau tshaj 1000ppm |
ua raws |
|
Hnyav hlau |
Tsis ntau tshaj 20 ppm |
Ua raws |
|
Assay |
98.5%---101.5% |
99.60% |
|
Cov txiaj ntsig: Cov txiaj ntsig tau ua raws li USP-38 specification |
||
Siv
1. Orlistat hmoov yog siv los kho kev rog. Tus nqi ntawm kev poob phaus ua tiav nrog orlistat sib txawv. Hauv kev sim tshuaj ib xyoos, nyob nruab nrab ntawm 35.5% thiab 54.8% ntawm cov neeg kawm tiav 5% lossis ntau dua qhov txo qis hauv lub cev, txawm tias tsis yog tag nrho cov loj no yuav tsum muaj roj. Nyob nruab nrab ntawm 16.4% thiab 24.8% ua tiav tsawg kawg yog 10% txo qis hauv lub cev rog. Tom qab cov hmoov orlistat raug tso tseg, cov neeg mob tseem ceeb tau nce qhov hnyav-txog 35% ntawm qhov hnyav lawv tau poob.
2. Qhov tshwm sim ntawm hom 2 mob ntshav qab zib mellitus hauv cov neeg rog rog dhau plaub xyoos yog txo qis nrog orlistat (6.2%) piv rau cov placebo (9.0%). Kev siv lub sijhawm ntev ntawm orlistat kuj ua rau txo qis hauv ntshav siab (txhais tau tias txo qis ntawm 2.5 thiab 1.9 mmHg hauv systolic thiab diastolic ntshav siab feem).
Muaj nuj nqi
1) Txo qhov mob plab thiab kub siab los ntawm hyperacidity: Orlistat tuaj yeem cuam tshuam cov haujlwm ntawm cov twj tso kua mis proton ntawm lub plab phab ntsa ua lub luag haujlwm rau kev tso tawm ntawm gastric acid, txo qhov tso tawm ntawm gastric acid, yog li txo cov tsos mob ntawm mob plab thiab kub siab.
2) Tswj cov kua qaub reflux: Orlistat tuaj yeem txo cov kua qaub hauv plab thiab txo qhov tshwm sim ntawm cov kua qaub reflux, yog li txo qhov tsis xis nyob los ntawm cov kua qaub reflux.
3) Kev kho kab mob peptic ulcer: Orlistat tuaj yeem txo qis cov kua qaub hauv plab, pab kho cov kab mob peptic, thiab tiv thaiv kev rov ua dua ntawm qhov txhab.
4) Tiv thaiv plab hnyuv puas los ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAIDs): Orlistat tuaj yeem txo cov kua qaub kua qaub los ntawm NSAIDs thiab txo qhov kev pheej hmoo ntawm kev puas tsuaj rau plab hnyuv.
5) Cov txheej txheem ntawm kev txiav txim ntawm orlistat yog txhawm rau txo qis qab los noj mov los ntawm kev cuam tshuam nrog lub qab los noj mov chaw hauv lub hlwb. Nws tuaj yeem ua rau kom satiety, txo cov khoom noj kom tsawg, thiab ua kom lub sijhawm ntev ntawm satiety. Tsis tas li ntawd, orlistat tseem tuaj yeem txo qhov kev ntshaw rau cov zaub mov muaj calorie ntau ntau, ua kom yooj yim rau tib neeg los tswj lawv cov zaub mov.
Orlistat kuj tseem tuaj yeem ua rau nce qhov basal metabolic tus nqi, txhawb kev rog rog thiab siv zog.
6) Kev kho tus kab mob gastroesophageal reflux (GERD): Orlistat tuaj yeem txo qis cov kua qaub hauv plab thiab txhim kho cov tsos mob ntawm tus kab mob gastroesophageal reflux, xws li kua qaub reflux thiab kub hnyiab hauv siab.
Orlistat ua haujlwm li cas?
Orlistat yog cov tshuaj poob phaus uas hloov pauv koj lub cev nqus cov rog los ntawm cov zaub mov koj noj. Orlistat tiv thaiv koj lub cev tawg ze li ntawm 1/3 ntawm cov rog uas koj noj.
Orlistat txuas rau cov enzymes hauv koj lub plab zom mov (lipases) thiab txwv tsis pub lawv tawg qee cov roj uas koj tau noj hauv koj cov zaub mov. Cov roj undigested tsis absorbed rau hauv koj lub cev thiab kis tawm nrog koj cov quav (faeces).
Orlistat siv sijhawm ntev npaum li cas los ua haujlwm?
Orlistat pib cuam tshuam li cas koj zom cov rog hauv 1 mus rau 2 hnub. Thaum noj Orlistat koj yuav tsum tau ua raws li kev npaj noj zaub mov kom txo qis calories thiab ua haujlwm tsis tu ncua kom tau txais txiaj ntsig zoo tshaj plaws. Kev hloov pauv txoj kev ua neej ntau dua koj ua qhov hnyav dua koj yuav poob. Saib rau cov cim qhia tsis zoo ntawm kev poob phaus es tsis txhob tsom mus rau qhov ntsuas los pab taug qab koj qhov kev nce qib.
Cim npe nrov: Orlistat nyoos hmoov, Tuam Tshoj Orlistat nyoos hmoov manufacturers, lwm tus neeg, Hoobkas
