Nefiracetam

Khoom npe: Nefiracetam

CAS: 77191-36-7

MF: C14H18N2O2

PIB: 246.3

EINECS: 636-080-4

Qeb: Nootropic

Nefiracetam Cov Khoom Siv Tshuaj

 

Melting point: 151-155 degree

Kub taw tes: 458.5 ± 33. 0 degree (Predicted)

Qhov ceev: 1.187 ± {2}}.06 g / cm3 (Predicted)

Cia temp.: kaw hauv qhuav, Chav Kub

Solubility: DMSO: >5 mg/ml

Cov tsos mob: dawb mus rau cov hmoov dawb dawb

Nefiracetam yog cov roj-soluble nootropic hauv racetam-chav kawm ntawm cov tebchaw. Nefiracetam suav hais tias muaj zog tshaj li thawj racetam, Piracetam.

Nws zoo ib yam hauv cov qauv rau Piracetam nrog ib pawg phenyl thiab ob pawg methyl ntxiv rau amine ntawm Piracetam. Nefiracetam, zoo li tag nrho cov racetam nootropics, muaj pyrrolidone nucleus ntawm nws cov tub ntxhais.

Cov qauv ntawm Nefiracetam zoo ib yam li Aniracetam.

Nefiracetam yog siv los ua tshuaj kho mob hauv Nyiv. Thiab ua ib qho ntxiv hauv Tebchaws Meskas. Zoo li tshiab rau cov zej zog nootropics. Neurohackers siv Nefiracetam los txhawb kev kawm, kev paub thiab kev nco.

Nefiracetam pab:

• Neuroprotection: Nefiracetam pab tswj NMDA signaling uas tiv thaiv cov qib glutamate ntau dhau. Glutamate yog qhov muaj zog excitatory neurotransmitter. Ntau dhau glutamatedamages neurons thiab tag nrho lub hlwb.
• Neurotransmitters: Nefiracetam modulates GABA qib hauv lub hlwb. Txo GABA thaum nws siab dhau, thiab nce GABA qib yog tias lawv qis dhau. Tsim kom muaj kev sib haum xeeb zoo li kev xav thiab txo kev ntxhov siab. Nefiracetam prolongs qhib cov calcium raws. Ua kom cov neurotransmitters ua haujlwm ntev dua. Txhim kho lub cim xeeb tsim thiab nco qab.
• Acetylcholine: Nefiracetam potentiates nicotinic acetylcholine receptors. Boosting tso tawm GABA thiab glutamate. Tsim cov nyhuv calming thaum txhim kho neuroplasticity thiab txhawb kev kawm thiab nco.

• Nefiracetam yog fat-soluble thaum Piracetam yog dej-soluble. Cov roj-soluble molecules hla cov ntshav-hlwb barrier yooj yim dua li dej-soluble molecules.
• Ob leeg Nefiracetam thiab Piracetam yog kev txawj ntse txhim kho. Thiab ob qho tib si muaj cov txiaj ntsig neuroprotective. Ob leeg racetams tuaj yeem txhim kho kev kawm thiab kev nco. Thiab ob leeg muaj peev xwm tiv thaiv lub hlwb puas.
• Nefiracetam muaj cov txiaj ntsig ntxiv uas tsis koom nrog Piracetam. Nefiracetam tuaj yeem txo kev ntxhov siab thiab kev nyuaj siab. Thiab nthuav tawm ntau lwm lub cim xeeb txhim kho qhov zoo tshaj Piracetam.
• Nefiracetam nce lub sij hawm calcium channels hauv neurons tseem qhib. Muab khi rau cov protein kinase A (PKA) thiab Gi alpha subunit (Gi/o protein), kev taw qhia tau txhim kho hauv cov neuroreceptor ywj pheej ntawm synapse. Txoj kev calcium channel no tseem ceeb heev rau kev muaj peev xwm mus sij hawm ntev (LTP) thiab tsim kom muaj kev nco mus ntev.
• Nefiracetam kuj potentiates protein kinase C alpha (PKC) uas koom nrog rau lub sij hawm ntev potentiation (LTP). PKC yog nyob ntawm glutamate signaling.
• Thiab Nefiracetam activates Ca2+/calmodulin-dependent protein kinase II (CaMKII) uas yog ib qho tseem ceeb hauv kev nco. Ib zaug ntxiv nyob ntawm glutamate signaling.
• Thaum kawg, Nefiracetam potentiates acetylcholine receptors hauv hippocampus uas txhawb nqa glutamate tso tawm thiab LTP. Piracetam tsis qhia qhov kev nco ua kom zoo.

Cov kab hauv qab yog Nefiracetam zoo li yog lub cim xeeb muaj zog ntau ntxiv uas tus thawj nootropic Piracetam.

Nefiracetam modulates GABA (gamma aminobutyric acid) hauv koj lub hlwb. GABA yog thawj inhibitory neurotransmitter hauv lub hlwb. Nws lub luag haujlwm yog khaws glutamate, qhov tseem ceeb tshaj plaws ntawm cov neurotransmitter los ntawm kev cuam tshuam koj lub hlwb. Thiab ua rau kev puas tsuaj.

Thaum GABA qib qis dhau lawm, koj muaj kev ntxhov siab, pw tsaug zog, tsis zoo thiab tsis xis nyob. Sab laug tsis kuaj nws tuaj yeem ua rau muaj kab mob neurodegenerative thiab lub neej tsis zoo.

Tab sis thaum GABA siab dhau lawm, koj muaj ib puag ncig lom hauv koj lub hlwb. Ua rau muaj kev puas tsuaj rau cov neurons thiab lwm qhov chaw ntawm koj lub hlwb. Nefiracetam modulates GABA qib, ua kom lawv ruaj khov rau lub hlwb noj qab haus huv. Thiab txhim kho kev nco mus ntev.

Nefiracetam pab txhawb kev kawm los ntawm kev txhim kho lub sijhawm ntev (LTP). Txhim kho NMDA-dependent LTP ntawm qhov tsis tshua muaj siab thiab AMPA nyob ntawm LTP ntawm qhov siab dua.

Nefiracetam ua ke nrog choline boosts zus tau tej cov neurotransmitter tseem ceeb acetylcholine. Txhim kho kev nco, nco qab thiab ua kom pom tseeb.

Nefiracetam yog fat-soluble thiab nkag mus rau koj lub hlwb sai sai tom qab koj noj nws. Ib zaug nyob rau hauv koj lub hlwb, nws boosts teeb liab kis tau tus mob, thiab tiv thaiv neurons.

Nefiracetam boosts acetylcholine ces koj yuav tsum coj nws nrog ib tug zoo choline qhov chaw. Sim Alpha GPC lossis CDP-Choline nrog Nefiracetam. Thiab muab koj lub hlwb cov choline nws xav tau.

Kev ntxiv ntawm nefiracetam zoo nkaus li nyob rau hauv {{0}}mg ntau dhau ntawm ib hnub (feem ntau muab faib ua peb koob tshuaj). Cov kev tshawb fawb tsiaj uas siv cov koob tshuaj mob hnyav yuav nco ntsoov cov txiaj ntsig feem ntau hauv 3-10mg / kg ntau, thiab qhov no cuam tshuam rau tib neeg koob tshuaj ntawm 0.48-1.6mg / kg (rau ib tus neeg 150 lb, {{6 }}mg) uas zoo ib yam li cov tshuaj tib neeg tau hais tseg.

Txawm hais tias ib koob tshuaj nefiracetam tsis tshwm sim los txhawb kev paub, nws muaj peev xwm cuam tshuam rau lub hlwb hauv 30-60 feeb tom qab noj qhov ncauj. Nws tsis paub meej tias nefiracetam yuav tsum tau noj ua ntej kev kawm paub.

Cim npe nrov: Nefiracetam, Tuam Tshoj nefiracetam lwm tus neeg