Ivermectin

Ivermectin Cov Ntaub Ntawv Tseem Ceeb

 

Khoom npe: Ivermectin

CAS: 70288-86-7

MF: C48H74O14

MW: 875.09

EINECS: 274-536-0

Cov tsos mob: Dawb hmoov

Ivermectin tseem hu ua Ivomec, yog ib hom tshuaj uas muaj txiaj ntsig zoo rau kev kho kab mob mite.Nws yuav ua rau muaj tshuaj lom yog tias overcommit ted. Cov tsos mob ntawm ivermectin lom yog raws li nram no: ntuav, ua pa nrawm, tsis muaj zog thiab tuag tes tuag taw hauv caj npab thiab txhais ceg, thiab lub plawv tsis ua haujlwm uas yuav ua rau tuag taus.

Kev cawm:Tsuas yog noj taum taum licorice haus detoxification nrog 10% qabzib thiab txhaj tshuaj dexamethasone thaum tsim nyog.

Ivermectin yog dawb los yog lub teeb daj crystalline hmoov thiab soluble nyob rau hauv methyl cawv, ester thiab aromatic hydrocarbon tab sis dej. Ivermectin yog ib hom tshuaj tua kab mob uas muaj kev tsav tsheb thiab tua cov kab mob nematodes, kab thiab mites. Kev txhaj tshuaj thiab troche uas yog tsim los ntawm ivermectin feem ntau yog siv rau hauv kev kho tsiaj cov tsiaj nyeg plab hnyuv nematode, bovine hypodermosis, calf ya maggot, yaj nasal ya maggot, thiab scabies ntawm yaj thiab npua. Tsis tas li ntawd, ivermectin tseem tuaj yeem muaj rau kev kho mob ntawm cov nroj tsuag-parasitic nematodes (ascarid, lungworm) hauv cov nqaij qaib. Tsis tas li ntawd, nws tseem tuaj yeem ua rau cov tshuaj tua kab tua kab tua kab, plutella xylostella, kab ntsig kab ntsig, nplooj miner, phylloxera thiab nematode uas yog cov kab mob dav dav hauv cov nroj tsuag. Qhov zoo tshaj plaws ntawm cov tshuaj tua kab no yog tias nws muaj cov kev mob tshwm sim me me thiab tuaj yeem tsav thiab tua ntau yam kab mob ntawm sab hauv thiab sab nraud ntawm ib lub sijhawm.

Ivermectin yog ib hom tshuaj tua kab mob botanical uas yog ua los ntawm cynanchum komarovii, sophora alopecuroides thiab ntau lwm cov nroj tsuag thiab suav tshuaj ntsuab los ntawm kev sib tsoo, yaj, ntxiv cov txhawb nqa thiab nkag mus thiab ua cov khoom sib tov. Nws cov txheej txheem ua haujlwm feem ntau yog ua raws li kev sib cuag lom nrog lub plab toxicity raws li kev sib txuas ntxiv, uas muaj kev txhawb nqa ntawm cov nroj tsuag kev loj hlob. Nws tuaj yeem siv los tiv thaiv thiab tua txhua yam ntawm aphids thiab defoliators. Yog tias diluted nrog dej rau 1000-2000 zaug thiab spayed, nws cov nyhuv tswj tau ncav cuag 98%. Ivermectin yog ib tiam tshiab ntawm cov tshuaj tua kab botanical uas tsis muaj toxicity, tsawg residual thiab tsis muaj kev phom sij rau tib neeg, tsiaj txhu thiab ib puag ncig.

Cov tshuaj tua kab mob ntawm ivermectin yog inhibit qhov kev sib txuas ntawm chitin ntawm kab epicutile. Lub ntsiab tseem ceeb ntawm chlorbenzuron yog tshuaj lom hauv plab, tab sis nws tuaj yeem nkag mus rau hauv kab epicutile thiab siv tau. Kev tiv thaiv thiab kev kho defoliator muaj ntau yam zoo xws li kev ua haujlwm tshwj xeeb, cov txiaj ntsig zoo, lub sijhawm ntev residual, tsis tshua muaj nqi, ua siab ntev rau cov dej nag, tsis yooj yim los tsim cov tshuaj tua kab thiab muaj kev nyab xeeb rau cov nroj tsuag, tib neeg, tsiaj txhu thiab ib puag ncig.

1. Ivermectin muaj rau kev tswj thiab kho onchocerca volvulus, thiab nws cov nyhuv tsis zoo yog qis dua li ntawm carbamazine.
2. Ivermectin tuaj yeem siv los ua ib hom tshuaj tiv thaiv kab mob thiab muaj kev ua haujlwm anthelmintic rau nematode, hookworm, roundworm, worm, kab thiab mite.

Ob lub tswv yim ntawm kev txiav txim yog xav tias yuav koom nrog hauv qhov kev txiav txim ntawm IVM. Thawj yog qhov kev txiav txim tsis ncaj uas qhov kev hloov pauv ntawm microfalaria txo qis, uas tso cai rau cytotoxic hlwb ntawm tus tswv tsev kom ua raws li cov kab mob cab, ua rau tshem tawm ntawm tus tswv tsev. Qhov kev txiav txim no yuav tshwm sim los ntawm kev tsim txiaj ntawm lub peev xwm ntawm IVM los ua ib qho -aminobutyric acid (GABA) agonist los yog ua tus inducer ntawm chloride ion influx, ua rau hyperpolarization thiab cov leeg leeg tuag tes tuag taw. Cov tshuaj chloride ion influx zoo nkaus li yog qhov plausible mechanism. Tsis ntev los no, nws tau pom tias IVM khi irreversibly rau glutamate-gated chloride channel ntawm nematode Haemonchus contortus, whereas lub channel yog nyob rau hauv ib tug qhib conformation. Kev khi ces tseem kaw rau hauv qhov qhib conformation, tso cai rau ions hla daim nyias nyias, ua rau tuag tes tuag taw ntawm IVM. Qhov tshwm sim ntawm qhov kev ua no yog qhov txo qis hauv microfilarial concentrations sai.

Qhov thib ob ua ntawm IVM ua rau lub degeneration ntawm microfilariae hauv utero. Qhov kev ua no yuav ua rau tsawg dua microfilariae raug tso tawm los ntawm cov poj niam worms, thiab nws tshwm sim nyob rau lub sijhawm ntev. Lub xub ntiag ntawm degenerated microfilariae nyob rau hauv utero tiv thaiv ntxiv fertilization thiab zus tau tej cov microfilariae.

Cim npe nrov: Tuam Tshoj ivermectin lwm tus neeg