DHT

DHT COV NTAUB NTAWV

 

Khoom npe: Stanolone

Synonyms: DHT; Dihydrotestosterone

CAS: 521-18-6

MF: C19H30O2

PIB: 290.45

EINECS: 208-307-3

Yam khoom: Steroid thiab Hormone

Mol File: 521-18-6.mol

Stanolone Chemical Properties

 

Melting point: 178-183 degree

Alpha: 27 º

Kub taw tes: 372.52 degree (nrawm kwv yees)

Qhov ceev: 1.0320 (nruab nrab kwv yees)

Refractive Index: 1.4709 (kwv yees)

fp:9 qib

Cia kub: 2-8 degree

Solubility: acetonitrile: 1 mg / ml; Ethanol: 1 mg / ml; Methanol: 1 mg / ml

Pka: 15.

Dej Solubility: 344.3g / L (kub tsis tau teev)

Daim ntawv: Dawb Fine hmoov

Dihydrotestosterone, ib qho tshuaj hormones uas muaj zog androgenic ua, ua rau lub cev loj hlob thaum lub hnub nyoog laus laus thiab muaj lub luag haujlwm rau ntau yam ntawm lub cev nrog rau cov txiv neej laus.

DHT ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm kev sib deev ntawm cov txiv neej. Thaum lub sij hawm embryonic lub neej, DHT koom nrog feem ntau hauv kev sib deev sib txawv ntawm lub cev. Los ntawm kev hluas thiab kev laus, DHT txhawb nqa kev loj hlob ntawm prostate, kev ua haujlwm ntawm qog sebaceous, txiv neej qauv tawv nqaij, thiab lub cev, lub ntsej muag, thiab cov plaub hau loj hlob.

Dihydrotestosterone yog ib yam tshuaj uas txhawb kev loj hlob ntawm txiv neej tus yam ntxwv (ib qho androgen). Nws yog tsim los ntawm kev hloov dua siab tshiab ntawm cov feem ntau paub androgen, testosterone. Yuav luag 10% ntawm testosterone tsim los ntawm ib tug neeg laus txhua hnub yog hloov mus rau dihydrotestosterone. Qhov no tshwm sim hauv cov qog ntshav thiab prostate (hauv txiv neej), hauv zes qe menyuam (hauv poj niam), nrog rau daim tawv nqaij thiab lwm qhov ntawm lub cev xws li daim siab. Cov duab no yog qis dua ua ntej kev ua hluas tiam sis, thiab nws tau xav tias qhov nce dihydrotestosterone ntau lawm tuaj yeem ua lub luag haujlwm rau qhov pib ntawm cov tub hluas, ua rau kev loj hlob ntawm qhov chaw mos (qhov noov, testes thiab scrotum) thiab kev loj hlob ntawm pubic thiab lub cev plaub hau. Cov tshuaj no kuj ua rau prostate loj hlob thiab xav tias yuav ua ke nrog testosterone ua rau kev qhia ntawm txiv neej tus cwj pwm. Dihydrotestosterone muaj ntau lub zog ntau dua li testosterone, thiab ntau qhov cuam tshuam uas testosterone muaj nyob hauv lub cev tsuas yog tshwm sim tom qab nws hloov mus rau dihydrotestosterone.

Ntau yam tsis paub txog qhov tseem ceeb ntawm dihydrotestosterone hauv cov poj niam, tab sis nws paub tias yuav ua rau ntau lub cev thiab cov plaub hau loj hlob pom hauv cov ntxhais tom qab puberty thiab tuaj yeem pab txiav txim siab lub hnub nyoog uas cov ntxhais pib laus.

DHT coj txoj kev loj hlob ntawm sab nraud genitalia, nrog rau qhov noov thiab scrotum, thiab lub caj pas prostate. Thaum cev xeeb tub, DHT ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm lub ntsej muag thiab lub cev plaub hau, nce cov leeg nqaij, thiab ua kom lub suab sib sib zog nqus.1

Kev cuam tshuam rau kev loj hlob ntawm kev sib deev

DHT muaj ntau yam cuam tshuam rau kev loj hlob ntawm kev sib deev thiab kev ua haujlwm ntawm kev sib deev, suav nrog:

• Pubic plaub hau loj hlob
• Lub ntsej muag plaub hau loj hlob
• Lub cev plaub hau loj hlob

Tshwj xeeb, DHT plays lub luag haujlwm tseem ceeb hauv kev txhim kho cov txiv neej sab nraud ntawm qhov chaw mos. Thaum puberty, DHT yog qhov tseem ceeb rau kev loj hlob ntawm noov. Nws ua haujlwm ua ke nrog testosterone kom nce qhov loj ntawm tus txiv neej sab nraud genitalia.

Qhov no tsis tau txhais hais tias noj testosterone los yog DHT yuav ua rau koj noov loj. Cov txiv neej laus uas tau ua tiav kev laus lawm tsis muaj androgen receptors hauv lawv cov nqaij mos.

Ntau dhau ntawm dihydrotestosterone, feem ntau tshwm sim los ntawm ntau tshaj testosterone ntau lawm, muaj qhov sib txawv ntawm cov txiv neej thiab poj niam. Nws tsis zoo li hais tias cov qib ntawm dihydrotestosterone yuav raug tsa ua ntej pib puberty. Nws kuj tseem tsis zoo li cov txiv neej laus uas muaj dihydrotestosterone ntau dhau lawm yuav tau txais kev hloov pauv. Cov poj niam uas muaj dihydrotestosterone ntau dhau tuaj yeem ua rau lub cev muaj zog, lub ntsej muag thiab cov plaub hau loj hlob (hu ua hirsutism), txwv tsis pub lub caij cev khaub ncaws (amenorrhoea) thiab pob txuv ntau ntxiv. Kev hloov pauv ntawm qhov chaw mos kuj tuaj yeem tshwm sim hauv cov poj niam uas muaj dihydrotestosterone ntau dhau.

Dihydrotestosterone tau xav tias muaj kev cuam tshuam tsawg dua rau cov poj niam thiab, vim li ntawd, nws ntseeg tau tias lawv tsis muaj kev cuam tshuam los ntawm kev muaj dihydrotestosterone tsawg dhau. Nws yog qhov ua tau, txawm li cas los xij, qhov pib ntawm kev puberty tuaj yeem ncua sijhawm rau cov ntxhais uas muaj dihydrotestosterone tsawg dhau thiab cov plaub hau ntawm lub cev thiab cov plaub hau tam sim no hauv cov poj niam laus kuj yuav raug txo.

Hauv qhov sib piv, cov theem qis ntawm dihydrotestosterone hauv cov txiv neej tuaj yeem muaj qhov cuam tshuam loj heev. Yog tias muaj dihydrotestosterone tsawg dhau thaum cov txiv neej fetuses tseem nyob hauv plab, piv txwv li, lawv yuav tsis yog 'masculinised' thiab lawv qhov chaw mos yuav zoo ib yam li qhov pom ntawm cov ntxhais ntawm tib lub hnub nyoog. Tom qab ntawd, cov tub hluas uas muaj dihydrotestosterone tsawg dhau tuaj yeem ua rau qee qhov kev hloov pauv feem ntau pom thaum muaj hnub nyoog laus dua (xws li cov leeg loj hlob thiab tsim cov phev) tab sis yuav tsis txhim kho lub cev plaub hau thiab kev loj hlob ntawm qhov chaw mos.

DHT thiab testosterone yog ob qho tib si cais ua androgens. Hauv lub cev, enzyme 5-alpha reductase hloov testosterone rau DHT.

DHT yog kwv yees nyob ib ncig ntawm tsib npaug zog dua li testosterone. DHT feem ntau yog tsim nyob rau hauv cov kabmob uas nws siv, xws li prostate.

Testosterone thiab DHT ob leeg khi rau tib receptors. Txawm li cas los xij, DHT ua tau zoo dua.

Feem ntau DHT thiab testosterone hauv lub cev yog khi rau cov proteins, xws li albumin thiab kev sib deev hormone-binding globulin hauv cov ntshav. Nrog DHT, tsawg dua 1% ntawm cov tshuaj hormones hauv cov ntshav yog ncig dawb. Qhov no yog me ntsis qis dua tus nqi ntawm kev pub dawb tiv thaiv testosterone.

Albumin tuaj yeem khi ntau ntawm testosterone lossis lwm yam tshuaj hormones kev sib deev tab sis khi cov tshuaj hormones tsis muaj zog. Kev sib deev hormone-binding globulin, hauv qhov sib piv, khi cov tshuaj hormones tsawg dua tab sis ua kom muaj zog dua.

Cim npe nrov: dht, Tuam Tshoj dht lwm tus neeg