17-Methlytestosterone hmoov

CAS Nr.: 58-18-4
Lub npe tshuaj: 17-Methyltestosterone
Synonyms: METHYLTESTOSTERONE
PIB: CB4213510
Cov mis mos molecular: C20H30O2
Molecular Luj: 302.46
Melting point: 162-168 degree (lit.)
Alpha: 79 º (c{1}}, cawv)
Boiling point: 383.47 degree (kwv yees ntxhib)
Qhov ceev: 1.0434 (nruab nrab kwv yees)
Refractive Index: 1.4800 (kwv yees)
Flash point: 5 degree
Cia kub: 2-8 degree
Solubility H2O: Tsawg dua los yog sib npaug rau 0.5 mg/mL

Txheej txheem cej luam
18-Methyltestosterone, ib qho hluavtaws derivative ntawm testosterone, yog ib qho tshuaj androgen thiab anabolic steroid (AAS). Nws yog tsuas yog siv nyob rau hauv kev kho mob ntawm qis testosterone theem nyob rau hauv cov txiv neej, ncua kev puberty nyob rau hauv cov tub hluas, nyob rau hauv tsawg koob tshuaj raws li ib feem ntawm menopausal hormone therapy rau menopausal tsos mob xws li kub flashes, osteoporosis, thiab kev sib deev tsis muaj siab nyob rau hauv cov poj niam, thiab kho mob cancer ntawm lub mis. hauv poj niam (1-3). Nws zoo nkaus li dawb los yog creamy dawb crystals los yog hmoov, uas yog soluble nyob rau hauv ntau yam organic sol vents tab sis yog xyaum insoluble nyob rau hauv dej. Nws yuav tsum raug tswj xyuas qhov ncauj.
19-Nws tau raug tsim tawm sai sai tom qab kev tshawb pom ntawm testosterone, yog ib qho ntawm thawj cov tshuaj AAS hluavtaws. 17-Methyltestosterone, dhau ntawm nws txoj haujlwm kho mob, kuj tuaj yeem siv los txhim kho lub cev thiab kev ua haujlwm, txawm hais tias nws tsis yog siv ntau li lwm yam AAS rau cov laj thawj zoo li no vim nws cov teebmeem androgenic, cov teebmeem estrogenic, thiab kev pheej hmoo ntawm daim siab puas. Cov tshuaj yog ib yam tshuaj uas tswj tau nyob rau hauv ntau lub teb chaws thiab yog li kev siv tsis yog kev kho mob feem ntau yog txhaum cai.

Nws tau raug siv los kho ntau yam tsos mob xws li hypogonadism, cryptorchidism, ncua kev puberty, thiab erectile kawg hauv cov txiv neej, thiab hauv cov koob tshuaj tsawg los kho cov tsos mob menopausal (tshwj xeeb yog rau pob txha, kub flashes, thiab ua kom libido thiab lub zog), tom qab yug me nyuam. mob lub mis thiab engorgement.

Hauv Asmeskas, 17-Methyltestosterone yog ib qho tshuaj anabolic steroid uas siv los kho cov txiv neej uas tsis muaj testosterone, hypogonadism thiab ncua kev puberty. Hypogonadism suav nrog ob hom thawj thiab hom hypogonadotropic: qhov qub tuaj yeem tshwm sim los ntawm cryptorchidism, ob tog torsions, orchitis, vanishing testis syndrome; los yog orchidectomy. Cov tom ntej no suav nrog idiopathic gonadotropin lossis LHRH tsis txaus, lossis pituitary hypothalamic raug mob los ntawm cov qog, raug mob, lossis hluav taws xob. Nws kuj tseem siv tau rau cov poj niam los kho mob qog noj ntshav, mob lub mis, o vim kev xeeb tub, thiab nrog rau kev sib ntxiv ntawm cov tshuaj estrogen tuaj yeem kho cov tsos mob ntawm tus poj niam cev xeeb tub. Nws kuj tau siv ua ke nrog esterified estrogens rau kev kho mob ntawm cov tsos mob ntawm cov tsos mob vasomotor nruab nrab rau cov poj niam laus.

17-Methyltestosterone yog siv rau qhov ncauj. Cov koob tshuaj tau pom zoo sib txawv nyob ntawm lub hnub nyoog, poj niam txiv neej, thiab kev kuaj mob ntawm tus neeg mob. Kev noj tshuaj yog kho raws li tus neeg mob cov lus teb thiab qhov tshwm sim ntawm qhov tsis zoo tshwm sim. Kev hloov kho hauv cov txiv neej uas tsis muaj androgen feem ntau xav tau 10 txog 50 mg ntawm 17-Methyltestosterone txhua hnub. Txawm li cas los xij, cov hnub nyoog raws sijhawm thiab cov pob txha pob txha yuav tsum tau muab coj los txiav txim siab ob qho tib si hauv kev txiav txim siab thawj koob tshuaj thiab hauv kev kho cov koob tshuaj. Cov koob tshuaj siv hauv kev kho mob ncua sij hawm puberty feem ntau yog nyob rau hauv qis qis ntawm cov lus qhia saum toj no, thiab rau lub sijhawm txwv, piv txwv li 4 mus rau 6 lub hlis. Rau kev kho mob ntawm cov poj niam mob qog noj ntshav, qhov koob tshuaj ntawm 17-Methyltestosterone hauv cov poj niam yog los ntawm 50-200 mg txhua hnub.

17-Methyltestosterone coj los ntawm ob lub hauv paus ntsiab lus: ua kom cov androgen receptor (ncaj qha lossis raws li DHT), thiab los ntawm kev hloov pauv mus rau estradiol thiab ua kom muaj qee yam tshuaj estrogen receptors.
17-Methyltestosterone tuaj yeem nkag mus rau hauv lub hom phiaj cov ntaub so ntswg, khi rau androgen receptor, lossis raug txo rau 5 -dihydrotestosterone (DHT) los ntawm cytoplasmic enzyme 5 -reductase. DHT khi rau tib lub androgen receptor txawm tias muaj zog dua, ua rau muaj zog dua androgenic potency. T-receptor lossis DHT-receptor complex tau dhau los ua qhov hloov pauv uas tso cai rau nws txav mus rau hauv lub cell nucleus thiab khi ncaj qha rau cov nucleotide ib ntus ntawm chromosomal DNA, uas yog hu ua cov ntsiab lus teb (HREs). Cov txheej txheem no tswj cov kev ua haujlwm ntawm ntau cov noob caj noob ces, ntxiv ua cov teebmeem androgen.

17-methyltestosterone tuaj yeem ua rau muaj ntau yam kev phiv tshuaj. Cov kev mob tshwm sim feem ntau suav nrog kev loj hlob ntawm lub ntsej muag / lub cev plaub hau, tawv taub hau plaub hau, nce aggressiveness, tawv nqaij, pob txuv, seborrhea, thiab kev sib deev tsav tsheb thiab erections spontaneous. Kuj tseem muaj qee yam kev mob tshwm sim estrogenic xws li mob lub mis, gynecomastia, kua dej tuav, thiab edema. Cov txiv neej tuaj yeem raug kev txom nyem hypogonadism, testicular atrophy, thiab thim rov qab infertility. Cov poj niam muaj peev xwm qee zaum raug kev txom nyem ib nrab irreversible virilization nrog rau clitoromegaly, lub mis atrophy, lub suab sib sib zog nqus, hirsutism thiab nqaij hypertrophy, raws li zoo raws li kev ua cev qhev thiab reversible infertility.

17-methyltestosterone kuj tseem tuaj yeem ua rau hepatotoxicity nrog rau siab siab enzymes, cholestatic jaundice, peliosis hepatis, hepatomas, thiab hepatocellular carcinoma. Nws kuj tuaj yeem cuam tshuam rau cov hlab plawv xws li ua rau erythropoiesis, nce qib hematocrit lossis txawm tias polycythemia, ntxiv rau cov xwm txheej thrombic xws li embolism thiab mob stroke. Thaum kawg, kev kho mob mus ntev ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav. Qee qhov xwm txheej hnyav kuj muaj xws li hypomania / mania, kev nyuaj siab, delusions, suicidality thiab psychosis.

Cim npe nrov: 17-methlytestosterone hmoov, Tuam Tshoj 17-methlytestosterone hmoov lwm tus neeg